Only a qualified physician in your state can determine if you qualify for and should undertake treatment. All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. This website is a repository of publicly available information and is not intended to form a physician-patient relationship with any individual. It reflects the genuine complexity of how individual men respond to hormonal treatment. However, recovery is not guaranteed for everyone, and timing matters, which is why fertility planning should be part of the conversation before starting TRT, not after. Testosterone therapy suppresses sperm production while in use, but for most men, that suppression is reversible after discontinuation, particularly with appropriate clinical support. In females assigned at birth (FAABs), they can help treat infertility. Monitoring estrogen levels and working with a healthcare provider to adjust the dosage can help mitigate these side effects. HCG dosing is determined independent from Testosterone levels or Testosterone dosing, and is generally based on desired use case. Zucker, Isaac, et al. "Efficacy and Safety of Human Chorionic Gonadotropin Monotherapy for Men with Hypogonadal Symptoms and Normal Testosterone," Cureus, vol. It’s known as the pregnancy hormone, but did you know that hCG can also be used as a treatment for low T? However, it may not be the best fit for those with severe testosterone deficiency or individuals seeking a less hands-on approach to treatment. Testosterone-only therapy is effective for many men and remains appropriate for those not concerned about fertility or testicular function. HCG monotherapy can be a powerful, fertility-preserving option for men whose testes retain the capacity to respond. The lack of research into hCG as a treatment for low testosterone levels means there is very little evidence regarding safe and effective dosages. Further high quality randomized controlled trials (RCTs) are necessary to help determine the extent to which hCG treatment could help prevent low testosterone levels. It also considers the scientific research into whether hCG could increase testosterone levels and the risks and considerations involved. This regimen provides peak within testosterone levels within the acceptable reference range during the first week after the injection 112,113. There is a greater risk of erythrocytosis with higher maximal peak in testosterone levels with IM injections when compared with transdermal formulations . TP with a short three-carbon ester is not used for testosterone replacement therapy because it lasts only for a few days. Testosterone replacement therapy will increase the growth and proliferation of androgen dependent prostate and male breast cancers. The dose of hCG should be adjusted until trough serum testosterone levels are restored to about the lower limit of the adult male range. Patients who are started on testosterone replacement therapy should be followed to ensure their symptoms/signs are improved after treatment. Significantly higher serum testosterone levels are attained with the new formulation and food intake improves the absorption 133,134. When injectable testosterone TU is used, serum testosterone levels should be measured prior to next injection to ensure the levels are at the lower limit of the reference range. To monitor serum testosterone levels after TE or TC injections some clinicians prefer that a blood sample be drawn midway between injections (e.g., at 7 days) and this should be within the mean serum testosterone seen in normal men. After TE or TC injection, serum testosterone levels peaked within 3 days and returned to baseline levels in about 2 weeks. Testosterone replacement therapy increases serum testosterone because of negative feedback on the hypothalamus and pituitary leads to lowering of intratesticular testosterone, affecting germ cell maturation and Sertoli cell function and consequent suppression of spermato-genesis.
